Mayzent

Mayzent
Generic Name: siponimod (sye POE ni mod)
Brand Names: Mayzent
Company: Novartis
FDA Approved: March 2019
Specific Treatments: relapsing multiple sclerosis
Rated: N/A

Mayzent will not cure MS, it will only decrease the frequency of relapse symptoms.

Mayzent is used only if you have a specific genotype. Your doctor will test you for this genotype.

Mayzent dosing information
Usual Adult Dose for Multiple Sclerosis:

CYP450 2C9 Genotype *1/*1, *1/*2, or *2/*2:
-Titration regimen: 0.25 mg orally once daily on Days 1 and 2, then 0.5 mg orally once daily on Day 3, then 0.75 mg orally once daily on Day 4, then 1.25 mg orally once daily on Day 5
-Maintenance dose: 2 mg orally once daily beginning on Day 6
NOTE: Use a starter pack for patients who will be titrated to the 2 mg maintenance dose.

CYP450 2C9 Genotype *1/*3 or *2/*3:
-Titration regimen: 0.25 mg orally once daily on Days 1 and 2, then 0.5 mg orally once daily on Day 3, then 0.75 mg orally once daily on Day 4
-Maintenance dose: 1 mg orally once daily beginning on Day 5
NOTE: Do not use the starter pack for patients who will be titrated to the 1 mg maintenance dose.
-If one titration dose is missed for more than 24 hours, therapy needs to be reinitiated with Day 1 of the titration regimen.